Growth Factor Transport Modeling

A major thrust of research of the Albro Lab is the development of sophisticated computational models to describe the delivery of key anabolic growth factors during the development of engineered musculoskeletal tissues. These novel frameworks can be used to optimize growth factor delivery strategies to allow for sufficient ECM biosynthesis during development while mitigating pathogenic effects of excessive growth factor activity that currently plague regenerative medicine platforms.

Transport of growth factor in articular cartilage can be described by a reaction diffusion equation which accounts for passive diffusion and chemical reactions (reversible binding to ECM and internalization by chondrocytes) within the engineered cartilage tissue.

In Vitro Tissue Growth

Bone

Cartilage

TGF-β level

(ng/mL)

48 h simulation

In Vivo Tissue Growth

This characterization allows for the development of the first-ever model to describe the transport of TGF-β in engineered cartilage tissues. We believe that this modeling framework will be applicable to a wide range of musculoskeletal tissue engineering systems:

  • Tissue types (e.g. cartilage, meniscus, tendons, IVD)

  • Scaffold materials (e.g. hydrogels, synthetic polymers)

  • Cell sources (e.g. chondrocytes, MSCs, other progenitors) 

Recent News

October 2020:  Professor Albro receives the Dr. James R. Neff Research Award from MTF Biologics

October 2020:  The Albro Lab is awarded Musculoskeletal Transplant Foundation Biologics Grant

 

May 2020:  The Albro and Bergholt Labs publish a new Raman paper in Optics Letters

May 2020:  Congratulations to Sung Yeon Kim for receiving the Earle and Mildred Bailey Memorial Award and the Adam Miller Award

May 2020:  Congratulations to the year's Albro Lab graduating seniors:  Sung Yeon Kim, Maggie Wu, and Zhonghao Dai

March 2020:  The Albro Lab is awarded the 2020 MSE Innovation Grant

February 2020:  The Albro and Bergholt Labs present their work on Raman spectroscopy for early OA diagnostics at SPIE Photonics West and the ORS Annual Meeting

 

 

 

 

OPEN POSITIONS