RESEARCH

Overview

The Growth Factor Mechanobiology Lab investigates an exciting, growing area of mechanobiology: the role of mechanical and extracellular interactions on the activity of growth factors in musculoskeletal tissues. Current research avenues focus on the following key areas: 1) understanding the role of mechanobiological phenomena on the development and degeneration of musculoskeletal tissues, 2) developing insight-based drug delivery platforms to halt the progression of tissue degeneration, 3) developing tissue engineering platforms to repair degenerated musculoskeletal tissues, and 4) spectroscopy-based diagnostics of connective tissue degeneration. The lab consists of a highly multidisciplinary environment with state of the art work performed in the areas of biomechanics, biochemistry, spectroscopy, and biomaterials science. 

Research Projects:

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Force-induced activation of growth factors

Scaffold growth factor conjugation

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Drug Delivery

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Targeted delivery of growth factor inhibitors

Reaction diffusion models of growth factors in engineered and native connective tissue

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Intra-articular Raman spectroscopy diagnostics