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A complete list of publications can be found here.

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Peer Reviewed Journal Articles

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  1. Kroupa K, Wu M, Zhang J, Wong W, Jensen M, Engiles JB, Grinstaff MW, Snyder B, Bergholt MS, Albro MB. Raman needle arthroscopy for in vivo molecular assessment of cartilage. Journal of Orthopaedic Research, 2021; 1-11. doi.org/10/1002/jor.25155

  2. Jensen M, Horgan CC, Vercauteren T, Albro MB, Bergholt MS. (2020) Multiplexed polarized hypodermic raman needle probe for biostructural analysis of articular cartilage: 45(10): 2890-3.

  3. Bergholt MS, Serio A, Albro MB. (2019) Raman imaging: Guiding light for the extracellular matrix. Frontiers in Bioengineering and Biotechnology, Nov 1; 7:303.

  4. Durney KM, Sharifi Kia D, Wang T, Singh A, Karbowski L, Koo HJ, Ateshian GA, Albro MB. (2019) Physiologic medium maintains the homeostasis of immature bovine articular cartilage explants in long-term culture. Journal of Biomechanical Engineering, Feb; 141. 

  5. Albro MB, Bergholt MS, St-Pierre JP, Vinals Guitart A, Zlotnick H, Stevens MM. (2018) Hyperspectral Raman imaging as a novel tool for quantifying the distribution of biochemical constituents in native and engineered cartilage. NPJ Regenerative Medicine, Feb 9; 3:3.

  6. Bergholt MS*, Albro MB*,Stevens MM. (2017) Online quantitative monitoring of live engineered cartilage growth using diffuse fiber-optic Raman spectroscopy. Biomaterials, Sept; 140:128-137. * Equal contribution.

  7. Bergholt MS, St-Pierre JP, Offeddu GS, Parmar PA, Albro MB, Puetzer JL, Oyen ML, Stevens MM. (2016) Raman spectroscopy reveals new insights into the zonal organization of native and tissue-engineered articular cartilage. ACS Central Science, 2 (12): 885-95.

  8. Cigan AD, Roach BL, Nims, RJ, Tan AR, Albro MB, Stoker AM, Cook JL, Vunjak-Novakovic G, Hung CT, Ateshian GA. (2016) High seeding density of human chondrocytes in agarose produces tissue-engineered cartilage approaching native mechanical and biochemical properties. J Biomechanics, 49 (9): 1909-17.

  9. Albro MB, Nims RJ, Durney KM, Cigan AD, Shim JJ, Vunjak-Novakovic G, Hung CT, Ateshian GA. (2016) Heterogeneous growth of engineered cartilage results from gradients of media-supplemented active TGF-beta and is ameliorated through the alternative supplementation of latent TGF-beta. Biomaterials, 77: 173-185.

  10. Nims RJ, Cigan AD, Albro MB, Vunjak-Novakovic G, Hung CT, Ateshian GA. (2015) Matrix production in large engineered cartilage constructs is enhanced by nutrient channels and excess media supply. Tissue Engineering Part C, 21 (7): 747-57.

  11. Cigan AD, Nims RJ, Albro MB, Vunjak-Novakovic G, Hung CT, Ateshian GA. (2014) Nutrient channels and stirring enhanced the composition and stiffness of large cartilage constructs. Journal of Biomechanics, 47 (16): 3847-54.

  12. Nims RJ, Cigan AD, Albro MB, Hung CT, Ateshian GA. (2014) Synthesis rates and binding kinetics of matrix products in engineered cartilage constructs using chondrocyte-seeded agarose gels. Journal of Biomechanics, 47 (9): 2165-72.

  13. Albro MB, Nims RJ, Cigan AD, Yeroushalmi KJ, Shim JJ, Hung CT, Ateshian GA. (2013) Dynamic mechanical compression of articular cartilage does not activate latent TGF-beta. Journal of Biomechanics, 46 (8): 1433-9.

  14. Cigan AD, Nims RJ, Albro MB, Esau JD, Dreyer MP, Vunjak-Novakovic G, Hung CT, Ateshian GA. (2013) Insulin, ascorbate, and glucose have a much greater influence than transferrin and selenous acid on the growth of engineered cartilage in chondrogenic media. Tissue Engineering Part A, 19(17-18): 1941-8.

  15. Albro MB, Nims RJ, Cigan AD, Alliston T, Hung CT, Ateshian GA. (2013) Accumulation of exogenous active TGF-beta in the superficial zone of articular cartilage. Biophysical Journal, 104 (8): 1794-804.

  16. Albro MB, Cigan AD, Nims RJ, Oungoulian SR, Yeroushalmi KJ, Hung CT, Ateshian GA. (2012) Shearing of synovial fluid activates latent TGF-beta. Osteoarthritis & Cartilage, 20(11): 1374-82.

  17. O’Connell GD, Lima EG, Bian L, Chahine NO, Albro MB, Cook JL, Ateshian GA. (2012) Toward engineering a biological joint replacement. Journal of Knee Surgery. 25: 187-96.

  18. Ateshian GA, Albro MB, Maas S, Weiss JA. (2011) Finite element implementation of mechanochemical phenomena in neutral deformable porous media under finite deformation. Journal of Biomechanical Engineering, 133(8): 081005.

  19. Albro MB, Banerjee RE, Li R, Oungoulian SR, Chen B, del Palomar AP, Hung CT, Ateshian GA. (2011) Dynamic loading of immature epiphyseal cartilage pumps nutrients out of vascular canals. Journal of Biomechanics, 44(9): 1654-9.

  20. Albro MB, Li R, Banerjee RE, Hung CT, Ateshian GA. (2010) Validation of theoretical framework explaining active solute uptake in dynamically loaded porous media. Journal of Biomechanics, 43(12): 2267-73.

  21. Albro MB, Petersen LE, Li R, Hung CT, Ateshian GA. (2009) Influence of the partitioning of osmolytes by the cytoplasm on the passive response of cells to osmotic loading. Biophysical Journal, 97(11): 2886-93.

  22. Albro MB, Rajan V, Li R, Hung CT, Ateshian GA. (2009) Characterization of the concentration-dependence of solute diffusivity and partitioning in a model dextran-agarose transport system. Cellular and Molecular Bioengineering, 2(3): 295-305.

  23. Chahine NO, Albro MB, Lima EG, Wei VI, Dubois CR, Hung CT, Ateshian GA. (2009) Effect of dynamic loading on the transport of solutes into agarose hydrogels. Biophysical Journal, 97(4): 968-975.

  24. Albro MB, Chahine NO, Li R, Yeager K, Hung CT, Ateshian GA. (2008) Dynamic loading of deformable porous media can induce active solute transport. Journal of Biomechanics, 41(15): 3152-3157.

  25. Azeloglu EU, Albro MB, Thimmappa V, Ateshian GA, Costa KD. (2008) Heterogeneous transmural proteoglycan distribution provides a mechanism for regulating residual stresses in the aorta. AJP Heart and Circulatory Physiology, 294(3): H1197-1205.

  26. Albro MB, Chahine NO, Caligaris M, Wei VI, Likhitpanichkul M, Ng KW, Hung CT, Ateshian GA. (2007) Osmotic loading of spherical gels: A biomimetic study of hindered transport in the cell protoplasm. Journal of Biomechanical Engineering, 129(4): 503-510.

 

 

Conference Abstracts

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  1. Kazemi M, Mehrotra DR, Zhang J, Yu C, Desai D, Grinstaff MW, Snyder BD, Bergholt MS, Albro MB. (2022) Raman needle probe assessment of cartilage composition predicts functional tissue properties. Annual Meeting of the Orthopaedic Research Society, abstract no. 2164.

  2. Mehrotra DR, Zhang J, Wang T, Ersland E, Grinstaff MW, Snyder BD, Bergholt MS, Albro MB. (2022) Raman arthroscopic needle probe for assessment of neocartilage composition. Annual Meeting of the Orthopaedic Research Society, abstract no. 223.

  3. Wang T, Martin A, Dai Z, Liu Y, Murphy-Ullrich JE, Grinstaff MW, Albro MB. (2022) A bio-inspired latent TGF-beta conjugated hyaluronan scaffold for cartilage tissue engineering. Annual Meeting of the Orthopaedic Research Society, abstract no. 217.

  4. Lyu Y, Wang T, Liu Y, Albro MB. (2022) Culture medium replenishment is not required to generate functional engineered cartilage in vitro. Annual Meeting of the Orthopaedic Research Society, abstract no. 1502.

  5. Wang T, Martin A, Dai Z, Liu Y, Murphy-Ullrich JE, Grinstaff MW, Albro MB. (2021) Latent TGF-beta conjugated scaffold improve functional properties and cell morphology in engineered cartilage. Next Generation of Tissue Engineers Trainee Symposium.

  6. Zhang J, Wang T, Jensen M, Grinstaff MW, Snyder BD, Bergholt MS, Albro MB. (2021) Raman needle arthroscopy towards in vivo monitoring of engineered cartilage growth. Summer Biomechanics, Bioengineering, and Biotransport Conference (SB3C), abstract no. 562.

  7. Jensen M, Horgan CC, Zhang J, Wu M, Vercauteren T, Snyder BD, Albro MB, Bergholt MS. (2021) Raman needle probe for compositional and structural analysis of articular cartilage during early osteoarthritis. SPIE BiOS Photonics West.

  8. Zhang J, Jensen M, Grinstaff MW, Schaer T, Snyder BD, Bergholt MS, Albro MB. (2021) Raman needle arthroscopy for in vivo diagnostics of musculoskeletal connective tissues. Annual Meeting of the Orthopaedic Research Society, abstract no. 1650-LB.

  9. Zhang J, Jensen M, Dogru S, Grande-Arriola H, Grinstaff MW, Snyder BD, Bergholt MS, Albro MB. (2021) Raman plate reader for quantitative molecular monitoring of live cartilage explants. Annual Meeting of the Orthopaedic Research Society, abstract no. 1604-LB.

  10. Wang T, Dai Z, Dogru S, Kim SY, Albro MB. (2021) Localized delivery of physiologic TGF-beta doses improves cell morphology in functional engineered cartilage. Annual Meeting of the Orthopaedic Research Society, abstract no. 713.

  11. Dogru S, Pierce K, Wang T, Albro MB. (2021) Patient-specific internalization rates mediate TGF-beta delivery in cartilage tissue engineering. Annual Meeting of the Orthopaedic Research Society, abstract no. 0020.

  12. Kim SY, Mosscrop M, Murphy-Ullrich JE, Albro MB. (2020). Novel quantification of mechanical load induced latent TGF-beta activation in articular cartilage. Summer Biomechanics, Bioengineering, and Biotransport Conference (SB3C).

  13. Kroupa K, Wu M, Wong W, Bergholt MS, Albro MB. (2020). Fiber-optic Raman spectroscopy for early-stage osteoarthritis diagnostics. Annual Meeting of the Orthopaedic Research Society (Podium presentation; Phoenix, AZ; Feb 2020).

  14. Dogru S, Dai Z, Albro MB. (2020). Dual compartmentalized functionality of TGF-beta in the synovial joint. Annual Meeting of the Orthopaedic Research Society (Podium presentation; Phoenix, AZ; Feb 2020).

  15. Simone NJ, Dogru S, Albro MB. (2020). Latent TGF-beta contents of synovial joint tissues. Annual Meeting of the Orthopaedic Research Society (Poster presentation; Phoenix, AZ; Feb 2020).

  16. Kroupa K, Wu M, Wong W, Bergholt MS, Albro MB. (2020). Fiber-optic Raman spectroscopy for early-stage osteoarthritis diagnostics. SPIE Photonics West (Podium presentation; San Francisco, CA; Feb 2020). 

  17. Kroupa K, Wu M, Wong W, Bergholt MS, Albro MB. (2020). Fiber-optic Raman spectroscopy for early-stage osteoarthritis diagnostics. SPIE Photonics West (Podium presentation; San Francisco CA; Feb 2020). 

  18. Albro MB. (2019) Computational models of growth factor delivery to engineered cartilage tissues. 16th International Symposium on Computer Methods in Biomechanics and Bioengineering. 

  19. Dogru S, Sharifikia D, Sze S, Albro MB. (2019) Concentration dependent TGF-beta internalization rate in engineered musculoskeletal tissues. Summer Biomechanics, Bioengineering, and Biotransport Conference. 

  20. Wang T, Berigei S, Wang Y, Grinstaff MW, Murphy-Ullrich JE, Albro MB. (2019) A latent TGF-beta scaffold improves engineered articular cartilage quality. 65th Annual Meeting of the Orthopaedic Research Society.

  21. Wang T, Kim S, Murphy-Ullrich JE, Albro MB. (2019) A novel autoinduction assay for quantifying exogenous TGF-beta activity in engineered tissues. 65th Annual Meeting of the Orthopaedic Research Society.

  22. Lawson TB, Albro MB, Snyder BD, Grinstaff MW. (2019) A cartilage interpenetrating polymer network decreases the partition coefficient of small biologically active molecules.  65th Annual Meeting of the Orthopaedic Research Society.

  23. Wang T, Sharifikia D, Baeyens S, Albro MB. (2018) Localization of delivery of moderated, near-physiologic levels of active TGF-beta can produce engineered cartilage of improved tissue quality. 2018 World Congress of Biomechanics.

  24. Albro MB, Bergholt MS, Stevens MM. (2017) Online quantitative monitoring of live engineered cartilage growth using diffuse fiber-optic Raman spectroscopy. 63rd Annual Meeting of the Orthopaedic Research Society. 

  25. Albro MB, Spicer CD, Ballinger M, Medina A, Littmann E, Stevens MM. (2016) Strategies for growth factor conjugation to acrylate-modified agarose scaffolds for cartilage tissue engineering. 62nd Annual Meeting of the Orthopaedic Research Society.

  26. Albro MB, Bergholt MS, St-Pierre JP, Zlotnick H, Medina A, Stevens MM. (2016) Hyperspectral Raman imaging as a novel tool for quantifying the distribution of biochemical constituents in native and engineered cartilage. 62nd Annual Meeting of the Orthopaedic Research Society.

  27. Albro MB, Durney KM, Shim JJ, Singh A, Ateshian GA, Stevens MM. (2015) Endogenous stores of latent TGF-beta serve to maintain the integrity and viability of articular cartilage over long term culture in response to physiologic and excessive dynamic mechanical loading. 61st Annual Meeting of the Orthopaedic Research Society.

  28. Albro MB, Nims RJ, Durney KM, Cigan AD, Shim JJ, Vunjak-Novakovic G, Hung CT, Ateshian GA. (2015) Heterogeneous growth of engineered cartilage results from gradients of media supplemented active TGF-beta and is ameliorated through the alternative supplementation of latent TGF-beta. 61st Annual Meeting of the Orthopaedic Research Society.

  29. Durney KM, Nims RJ, Albro MB, Karbowski L, Singh A, Vukelic S, Hung CT, Ateshian GA. (2015) Raman spectrographic characterization of cartilage matrix swelling via lysyl oxidase inhibition in immature explants and tissue constructs. 61st Annual Meeting of the Orthopaedic Research Society.

  30. Nims RJ, Cigan AD, Albro MB, Hung CT, Ateshian GA. (2015) Glucose- and TGF-beta-dependent matrix synthesis models explain heterogeneous matrix deposition in large engineered tissues. 61st Annual Meeting of the Orthopaedic Research Society.

  31. Cigan AD, Nims RJ, Albro MB, Jones BK, Feingold HJ, Hung CT, Ateshian GA. (2015) Characterization of a human chondrocyte-agarose system for engineering cartilage: The importance of cell seeding density. 61st Annual Meeting of the Orthopaedic Research Society.

  32. Albro MB,Durney KM, Shim JJ, Singh A, Cigan AD, Nims RJ, Jones BK, Hung CT, Ateshian GA. (2014) Synovial fluid and physiologic levels of cortisol, insulin, and glucose in media maintain the homeostasis of immature bovine cartilage explants over long-term culture. 60th Annual Meeting of the Orthopaedic Research Society.

  33. Albro MB,Durney KM, Shim JJ, Nims RJ, Cigan AD, Alliston T, Hung CT, Ateshian GA. (2014) Endogenous stores of latent TGF-beta function to maintain the mechanical integrity of articular cartilage independent of physiologic mechanical loading: Assessment through the novel validation of the specificity of a small molecule TGF-beta inhibitor. 60th Annual Meeting of the Orthopaedic Research Society.

  34. Cigan AD, Nims RJ, Albro MB, Ouien MM, Atkatsh KM, Hung CT, Ateshian GA. (2014) Elevated matrix production in large engineered cartilage constructs is facilitated by nutrient channels and sufficient media. 60th Annual Meeting of the Orthopaedic Research Society.

  35. Nims RJ, Cigan AD, Albro MB, Vunjak-Novakovic G, Hung CT, Ateshian GA. (2014) Inorganic sulfate supplementation is not required for extracellular matrix sulfation in long-term culture of engineered cartilage. 60th Annual Meeting of the Orthopaedic Research Society.

  36. Nims RJ, Cigan AD, Albro MB, Hung CT, Ateshian GA. (2013) Binding and release kinetics of glycosaminoglycans and collagen in engineered cartilage under TGF-beta supplementation. Proceedings of the 2013 ASME Summer Bioengineering Conference.

  37. Cigan AD, Nims RJ, Albro MB, Hung CT, Ateshian GA. (2013) Effects of media stirring and presence of nutrient channels on functional properties of large engineered cartilage constructs. Proceedings of the 2013 ASME Summer Bioengineering Conference.

  38. Nims RJ, Cigan AD, Albro MB, Park DB, Vunjak-Novakovic G, Hung CT, Ateshian GA. (2013) Engineered cartilage supplemented with channels increases nutrient availability throughout large constructs: A finite element study. Proceedings of the 11thInternational Symposium, Computer Methods in Biomechanics and Biomedical Engineering.

  39. Albro MB, Nims RJ, Cigan AD, Yeroushalmi KD, Shim J, Chen YBC, Hung CT, Ateshian GA. (2013) Dynamic mechanical compression of articular cartilage does not activate latent TGF-beta. 59th Annual Meeting of the Orthopaedic Research Society.

  40. Cigan AD, Nims RJ, Albro MB, Quien M, Vunjak-Novakovic G, Hung CT, Ateshian GA. (2013) Identification of a glucose concentration threshold critical for tissue growth in engineering cartilage. 59th Annual Meeting of the Orthopaedic Research Society. 

  41. Nims RJ, Cigan AD, Albro MB, O’Connell GD, Park DB, Hung CT, Ateshian GA. (2013) Frequent chondroitinase treatment in engineered cartilage with native levels of cell seeding density does not enhance collagen deposition and is detrimental to chondrocytes. 59th Annual Meeting of the Orthopaedic Research Society.

  42. Cigan AD, Nims RJ, Albro MB, Breves SL, Hung CT, Ateshian GA. (2012) Insulin and ascorbate have a much greater influence than transferrin and selenous acid on the growth of engineered cartilage in chondrogenic media. Proceedings of the 2012 ASME Summer Bioengineering Conference.

  43. Ateshian GA, Nims RJ, Cigan AD, Albro MB, Hung CT. (2012) Finite element modeling of matrix synthesis and binding kinetics in a biphasic-solute material. Proceedings of the 2012 ASME Summer Bioengineering Conference.

  44. Albro MB, Nims RJ, Cigan AD, Chen YBC, Hung CT, Ateshian GA. (2012) Accumulation of exogenous active TGF-beta in the superficial zone of immature bovine articular cartilage. 58th Annual Meeting of the Orthopaedic Research Society.

  45. Albro MB, Cigan AD, Nims RJ, Chen YBC, Hung CT, Ateshian GA. (2012) Synthesis and incorporation of latent TGF-binto the extracellular matrix of engineered cartilage constructs. 58th Annual Meeting of the Orthopaedic Research Society. 

  46. Nims RJ, Cigan AD, Albro MB,Wood KC, Hung CT, Ateshian GA. (2012) Engineered cartilage constructs retain a much greater fraction of synthesized GAG and collagen than COMP. 58th Annual Meeting of the Orthopaedic Research Society. 

  47. Albro MB, Oungoulian SR, Romeo R, Saniel CJ, Hung CT, Ateshian GA. (2011) Shear-induced activation of latent TGF-beta1 in synovial fluid. 57th Annual Meeting of the Orthopaedic Research Society.

  48. Oungoulian SR, Albro MB, Saniel CJ, Bell FA, Hung CT, Ateshian GA. (2011) The dose-dependent effect of TGF-beta1 on immature bovine articular cartilage properties during long term culture. 57th Annual Meeting of the Orthopaedic Research Society.

  49. Albro MB, Li R, Banerjee RE, Chen B, Oungoulian SR, del Palomar AP, Trubelja A, Hung CT, Ateshian GA. (2010) Loading of immature cartilage pumps transferrin out of blood vessel remnants and into the tissue matrix over short time scales. 56th Annual Meeting of the Orthopaedic Research Society, Vol. 35, Paper No. 0912.

  50. Oungoulian SR, Huynh MT, Albro MB, Barritt J, McDonald CA, Copperman AB, Elad D, Ateshian GA. (2010) Influence of the zona pellucida membrane stiffness on the passive response of oocytes to osmotic loading. World Congress of Biomechanics.

  51. Albro MB, Li R, Banerjee RE, Hung CT, Ateshian GA. (2009) Direct validation of active solute transport induced by dynamic loading. Proceedings of the 2009 ASME Summer Bioengineering Conference.

  52. Tan A, Dinh A, Albro MB, Ateshian GA, Hung CT. (2009) Type IX agarose gel produces better tissue engineered cartilage constructs than type VII agarose. 55th Annual Meeting of the Orthopaedic Research Society, Vol.34, Paper No. 1302.

  53. Albro MB, Li R, Yeager K, Hung CT, Ateshian GA. (2009) Dynamic loading of porous gels and cartilage can induce active solute transport. 55th Annual Meeting of the Orthopaedic Research Society, Vol. 34, Paper No. 0151. 

  54. Albro MB, Li R, Rajan V, Yeager K, Hung CT, Ateshian GA. (2008) Overcoming passive transport limitations: concentration enhancement through dynamic loading. SIAM Conference on Mathematical Aspects of Materials Science (MS08).

  55. Ateshian GA, Azeloglu EU, Albro MB, Costa KD. (2007) Mixture theory analysis of the interstitial growth of proteoglycans as a mechanism regulating residual stresses in biological tissues. Proceedings of the 44th Annual Technical Meeting of the Society of Engineering Science. 

  56. Azeloglu EU, Albro MB, Thimmappa V, Haggart C, Ng KW, Ateshian GA, Costa KD. (2007) The role of the proteoglycans on the residual stresses in the aorta. Proceedings of the 2007 ASME Summer Bioengineering Conference. 

  57. Albro MB, Rajan V, Hung CT, Ateshian GA. (2007) Fickian behavior and concentration-dependence of the diffusion of dextran in agarose. Proceedings of the 2007 ASME Summer Bioengineering Conference.

  58. Albro MB, Chao PG, Hung CT, Ateshian GA. (2007) Partial volume recovery of chondrocytes upon osmotic loading explained by the cytoplasm’s passive steric exclusion of select solute species. 53rd Annual Meeting of the Orthopaedic Research Society, Vol. 32, Paper No. 0151.

  59. Ateshian GA, Chahine NO, Wei VI, Albro MB, Hung CT. (2006) Computational methods for solute transport in soft tissues and tissue constructs under static and dynamic loading. Proceedings of the 5th World Congress of Biomechanics.

  60. Chahine NO, Lima EG, Wei VI, Albro MB, Hung CT, Ateshian GA. (2006) Effect of direct perfusion and dynamic loading on solute transport in patellar shaped constructs. Proceedings of the 2006 ASME Summer Bioengineering Conference.

  61. Chahine NO, Wei VI, Lima EG, Albro MB, Hung CT, Ateshian GA. (2006) Effect of perfusion and dynamic loading on the distribution and content of solutes in patellar shaped agarose constructs. 52nd Annual Meeting of the Orthopaedic Research Society, Vol. 31, Paper No. 0792.

  62. Albro MB, Chahine NO, Ng KW, Likhitpanichkul M, Hung CT, Ateshian GA. (2005) Osmotic loading of alginate gels: a biomimetic study of hindered transport in the cell cytoplasm. Proceedings of the 2005 ASME Summer Bioengineering Conference.

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PUBLICATIONS

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