The Growth Factor Mechanobiology Lab is currently recruiting doctoral students in Mechanical Engineering, Biomedical Engineering, and Material Science and Engineering. Email Prof. Michael Albro (firstname.lastname@example.org) for more information.
Postdoctoral Research Associate:
The Growth Factor Mechanobiology Lab (PI: Michael Albro) in the Boston University College of Engineering has an open position for a talented and highly motivated postdoctoral research associate with outstanding research credentials to work on an NSF-funded project in the area of growth factor mechanobiology in musculoskeletal connective tissues.
This research project builds upon an exciting growing area of mechanobiology: the role of physiologic mechanical loading on the activation of latent TGF-beta in articular cartilage. The project aims to: 1) perform novel quantitative measurements of the latent TGF-beta activation rate in response to physiologic/injurious loading regimens, 2) examine the functional role of TGF-beta activation in coordinating load-triggered repair of the cartilage matrix, and 3) examine the dissipation of this repair mechanism with age and osteoarthritis. The elucidation of this intrinsic mechanism and its limitations is likely to yield significant insights into the initiation of age and trauma-associated osteoarthritis.
In a parallel project, the postdoctoral research associate will have the opportunity to develop novel pharmacological therapeutic platforms to treat degenerative pathology. This work will utilize insights from these foundational basic-science advances in order to develop strategic, targeted molecular platforms to restore growth factor regulation and reverse growth-factor-mediated pathology.
Initial appointment is for one year; renewable for a second year.
The successful applicant will have a strong publishing record in orthopaedic mechanobiology or tissue engineering. Ideal candidates should have experience and expertise in at least some of the following areas:
Ex vivo tissue culture
Growth factor biochemical analytical techniques (ELISA, IHC, Westerns)
Microscopy techniques (confocal, second harmonic generation)
Tissue mechanical characterization techniques
Mechanical bioreactor utilization and development
To apply, please send a statement of interest, a CV, and the names of three references to Prof. Michael Albro (email@example.com).